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Flupen 500mg Capsule 1 Strip
Flupen is prescribed for treating infections caused by Gram-positive bacteria, including penicillinase-producing staphylococci. It is commonly used for:
✔ Skin and soft tissue infections – boils, abscesses, carbuncles, infected ulcers, eczema, acne, furunculosis, cellulitis, infected wounds and burns, otitis media and externa, and impetigo.
✔ Respiratory tract infections – pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, and quinsy.
✔ Other infections – osteomyelitis, enteritis, endocarditis, urinary tract infections, meningitis, and septicemia.
✔ Surgical prophylaxis – Used before major procedures such as cardiothoracic and orthopedic surgeries.
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✅ Description:
Flucloxacillin is a penicillinase-resistant antibiotic effective against Gram-positive bacteria but has minimal effect on Gram-negative organisms. It works by inhibiting bacterial cell wall synthesis, preventing bacterial growth and replication.
✔ It interferes with peptidoglycan synthesis, a crucial component that strengthens bacterial cell walls.
✔ It inhibits transpeptidase enzymes, leading to cell wall weakening and bacterial rupture.
✔ Flucloxacillin is resistant to bacterial penicillinase, making it effective against penicillin-resistant staphylococci.
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✔️ Dosage and Administration
Oral Dosage:
🔹 Adults – 250 mg four times daily; may be doubled for severe infections. In osteomyelitis and endocarditis, doses up to 8 g per day may be used in 6–8 hour intervals.
🔹 Children (2-10 years) – Half the adult dose.
🔹 Children (under 2 years) – Quarter of the adult dose.
✔ Severe renal impairment (Creatinine clearance <10 ml/min) – Requires dose adjustment or extended dosing intervals.
Parenteral Dosage:
🔹 Adults & Elderly:
- Intramuscular injection – 250 mg four times daily.
- Intravenous injection – 250 mg to 1 g four times daily (slow IV over 3–4 minutes or via infusion).
- For severe infections – Dosages may be doubled (up to 8 g per day in endocarditis or osteomyelitis).
🔹 Children:
- 2-10 years – Half of the adult dose.
- Under 2 years – Quarter of the adult dose.
💊 Oral doses should be taken 1 hour before meals.
🔹 Use only as directed by a registered physician.
✔️ Drug Interactions
Concurrent use of Flupen with certain medications may lead to prolonged elevated levels in the bloodstream. Always consult a doctor before combining it with other medicines.
✔️ Contraindications
❌ Not suitable for individuals allergic to penicillin.
✔️ Flupen may cause mild to moderate side effects, including:
✔ Gastrointestinal issues – nausea, vomiting, diarrhea, dyspepsia, and minor stomach discomfort.
✔ Allergic reactions – rashes, urticaria, purpura, and fever.
✔ Other complications – interstitial nephritis, hepatitis, and cholestatic jaundice.
✔️ Use During Pregnancy & Lactation
✔ Pregnancy Category B (US FDA): No confirmed risks in human studies, but should be used only if necessary during pregnancy.
✔ Excretion in breast milk: Flucloxacillin is present in human milk, so caution is advised for breastfeeding mothers.
✔️ Precautions & Warnings
✔ Use with caution in patients with liver disorders.
✔ Patients with a history of allergies should be monitored carefully.
✔️ Storage Conditions
✔ Store in a dry place away from direct light and heat.
✔ Keep out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
