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Flupen 500mg Capsule 1 Strip
Flupen is prescribed for treating infections caused by Gram-positive bacteria, including penicillinase-producing staphylococci. It is commonly used for:
✔ Skin and soft tissue infections – boils, abscesses, carbuncles, infected ulcers, eczema, acne, furunculosis, cellulitis, infected wounds and burns, otitis media and externa, and impetigo.
✔ Respiratory tract infections – pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, and quinsy.
✔ Other infections – osteomyelitis, enteritis, endocarditis, urinary tract infections, meningitis, and septicemia.
✔ Surgical prophylaxis – Used before major procedures such as cardiothoracic and orthopedic surgeries.
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✅ Description:
Flucloxacillin is a penicillinase-resistant antibiotic effective against Gram-positive bacteria but has minimal effect on Gram-negative organisms. It works by inhibiting bacterial cell wall synthesis, preventing bacterial growth and replication.
✔ It interferes with peptidoglycan synthesis, a crucial component that strengthens bacterial cell walls.
✔ It inhibits transpeptidase enzymes, leading to cell wall weakening and bacterial rupture.
✔ Flucloxacillin is resistant to bacterial penicillinase, making it effective against penicillin-resistant staphylococci.
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✔️ Dosage and Administration
Oral Dosage:
🔹 Adults – 250 mg four times daily; may be doubled for severe infections. In osteomyelitis and endocarditis, doses up to 8 g per day may be used in 6–8 hour intervals.
🔹 Children (2-10 years) – Half the adult dose.
🔹 Children (under 2 years) – Quarter of the adult dose.
✔ Severe renal impairment (Creatinine clearance <10 ml/min) – Requires dose adjustment or extended dosing intervals.
Parenteral Dosage:
🔹 Adults & Elderly:
- Intramuscular injection – 250 mg four times daily.
- Intravenous injection – 250 mg to 1 g four times daily (slow IV over 3–4 minutes or via infusion).
- For severe infections – Dosages may be doubled (up to 8 g per day in endocarditis or osteomyelitis).
🔹 Children:
- 2-10 years – Half of the adult dose.
- Under 2 years – Quarter of the adult dose.
💊 Oral doses should be taken 1 hour before meals.
🔹 Use only as directed by a registered physician.
✔️ Drug Interactions
Concurrent use of Flupen with certain medications may lead to prolonged elevated levels in the bloodstream. Always consult a doctor before combining it with other medicines.
✔️ Contraindications
❌ Not suitable for individuals allergic to penicillin.
✔️ Flupen may cause mild to moderate side effects, including:
✔ Gastrointestinal issues – nausea, vomiting, diarrhea, dyspepsia, and minor stomach discomfort.
✔ Allergic reactions – rashes, urticaria, purpura, and fever.
✔ Other complications – interstitial nephritis, hepatitis, and cholestatic jaundice.
✔️ Use During Pregnancy & Lactation
✔ Pregnancy Category B (US FDA): No confirmed risks in human studies, but should be used only if necessary during pregnancy.
✔ Excretion in breast milk: Flucloxacillin is present in human milk, so caution is advised for breastfeeding mothers.
✔️ Precautions & Warnings
✔ Use with caution in patients with liver disorders.
✔ Patients with a history of allergies should be monitored carefully.
✔️ Storage Conditions
✔ Store in a dry place away from direct light and heat.
✔ Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
